Napoli 2 - Liverpool 0 (Dries Mertes p-82', Fernando Llorente 90+2')
Red Bull Salzburg 6 - KRC Genk 2 (Erling Haland 2', 34', 45', Hwang Hee-chan 36', Dominik Szoboszlai 45+2', Andreas Ulmer 66'; Jhon Lucumi 40', Mbwana Samatta 52')
Inter Milan 1 - Slavia Praha 1 (Nicolo Barella 90+2'; Peter Olayinka 63')
Borussia Dortmund 0 - Barcelona 0
Olympique Lyon 1 - Zenit St. Petersburg 1 (Memphis Depay p-51'; Sardar Azmoun 41')
Benfica 1 - RB Leipzig 2 (Haris Seferovic 84'; Timo Werner 69', 78')
Ajax 3 - Lille 0 (Quincy Promes 18', Edson Alvarez 50', Nicolas Tagliafico 62')
Chelsea 0 - Valencia 1 (Rodrigo Moreno 74')
Klasemen Grup E
| Tim | M | M | I | K | Gol | P | |
| 1 | Red Bull Salzburg | 1 | 1 | 0 | 0 | 6-2 | 3 |
| 2 | Napoli | 1 | 1 | 0 | 0 | 2-0 | 3 |
| 3 | Liverpool | 1 | 0 | 0 | 1 | 0-2 | 0 |
| 4 | KRC Genk | 1 | 0 | 0 | 1 | 2-6 | 0 |
Klasemen Grup F
| Tim | M | M | I | K | Gol | P | |
| 1 | Slavia Praha | 1 | 0 | 1 | 0 | 1-1 | 1 |
| 2 | Inter Milan | 1 | 0 | 1 | 0 | 1-1 | 1 |
| 3 | Barcelona | 1 | 0 | 1 | 0 | 0-0 | 1 |
| 4 | Borussia Dortmund | 1 | 0 | 1 | 0 | 0-0 | 1 |
Klasemen Grup G
| Tim | M | M | I | K | Gol | P | |
| 1 | RB Leipzig | 1 | 1 | 0 | 0 | 2-1 | 3 |
| 2 | Zenit St. Petersburg | 1 | 0 | 1 | 0 | 1-1 | 1 |
| 3 | Olympique Lyon | 1 | 0 | 1 | 0 | 1-1 | 1 |
| 4 | Benfica | 1 | 0 | 0 | 1 | 1-2 | 0 |
Klasemen Grup H
| Tim | M | M | I | K | Gol | P | |
| 1 | Ajax | 1 | 1 | 0 | 0 | 3-0 | 3 |
| 2 | Valencia | 1 | 1 | 0 | 0 | 1-0 | 3 |
| 3 | Chelsea | 1 | 0 | 0 | 1 | 0-1 | 0 |
| 4 | Lille | 1 | 0 | 0 | 1 | 0-3 | 0 |
